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Sixty elderly men were put on various Ostarine dosages for 3 months, and it was found that simply taking 3mg of Ostarine per day led to an increase in muscle mass by 1.5% in men. Another important study comparing a variety of dosages of Ostarine was a study on women. The study found that Ostarine supplementation increased muscle mass in women after just 24 weeks. One study has shown that Ostarine can increase strength and fat burning, as well as reduce body fat while providing a reduction in insulin resistance. 3.2. Muscle Mass Ostarine is known to increase both circulating and intracellular levels of proteins associated with mitochondrial energy production, and in one study has been found to increase mitochondrial biogenesis, particularly myofibrillar protein synthesis. The increase in myofibrillar protein synthesis (MPS) and the ability of the mitochondria to incorporate nutrients into the myocyte cell membrane appears to be mediated via Ostarine intake, possibly via the enzyme osmotica. In addition, Ostarine reduces the amount of mitochondrium available to provide energy to the cell, and at the dose of 12mg/kg bodyweight of Ostarine, this reduction was associated with a 2.5% reduction in MPS and an 11.9% reduction in myofibrillar protein synthesis. The increase in mitochondrial ATP production also appears to be mediated by the effect of Ostarine on intracellular levels of fatty acids. Ostarine appears to be able to increase the muscle mass of the body when consumed in excess of a maintenance dose. 3.3. Muscle Structure In one study to study Ostarine's effects on the cellular structure of the myocytes, when the myocytes were incubated in Ostarine for 60 minutes, one can note myoblasts were more likely to have more mitochondria. 3.4. Fat Burning Obesity is a known contributor to reduced fitness, as this leads to a reduction in mitochondrial mass. The mitochondria have large molecular targets (the CpG island, the cytochrome P450 complex I, II, III, and IV and the mitochondria themselves), which have been known to be negatively impacted by Ostarine. A study assessing the effects of Ostarine in overweight and obese individuals noted that a single oral dose of 1-3g of Ostarine was able to increase energy expenditure by 20% and exercise tolerance by 42%, which was independent of changes in body fat distribution Related Article: